Is Modafinil Safe Long-Term?

Can modafinil cause memory loss?

We also examined modafinil (0.075 – 75 mg/kg) on Pavlovian fear conditioning.

A low dose of pre-training modafinil (0.75 mg/kg) enhanced memory of contextual fear conditioning (tested off-drug one week later) while a high dose (75 mg/kg) disrupted memory..

Is it safe to take modafinil everyday?

The recommended dose for modafinil is 200mg taken once daily [23]. Modafinil has been found to be well-tolerated, with a low incidence of adverse effects and low potential for abuse [24].

Can you lose weight with modafinil?

Reinstitution of modafinil resulted in a 10-lb. weight loss over a 6-week period. Conclusions: Modafinil treatment resulted in a significant weight loss in this patient, possibly due to reducing clozapine-associated fatigue.

How long does it take for modafinil to kick in?

For most people, it usually takes 30 to 60 minutes to start working. If you take Provigil with food, it might take slightly longer.

What is the genius pill?

Modafinil, sold under the name Provigil, is a stimulant that some have dubbed the “genius pill.” Originally developed as a treatment for narcolepsy and other sleep disorders, physicians are now prescribing it “off-label” to cellists, judges, airline pilots, and scientists to enhance attention, memory, and learning.

Does modafinil have withdrawal symptoms?

Many people do not report experiencing any withdrawal symptoms after discontinuing the use of modafinil. However, some people may experience Provigil withdrawal symptoms like: Poor concentration. Tiredness or fatigue.

Is modafinil good for anxiety?

Another study of mood and cognitive function in healthy young adults found that a single 100 mg dose of modafinil was associated with greater subjective and physical symptoms of anxiety than placebo, but a higher dose (200 mg) did not show these effects (Randall, Shneerson, Plaha, & File, 2003).

Does modafinil increase IQ?

However, interestingly, several interactions between modafinil and IQ emerged. Modafinil (100 and 200 mg) significantly improved target sensitivity in the RVIP test, but only in the group of ‘lower’ IQ (mean+/-sem=106+/-0.6), not in the ‘higher’ IQ group (mean+/-sem=115.5+/-0.5).

What happens if you take too much modafinil?

The most frequently reported clinical effects were tachycardia, insomnia, agitation, dizziness, and anxiety. A suicide attempt with modafinil overdose has not been described before.

Is modafinil bad for your heart?

Modafinil substantially perturbs autonomic cardiovascular regulation by increase in heart rate and blood pressure. Autonomic changes of this magnitude encourage caution in use of modafinil in patients with cardiovascular disease.

What does modafinil do to your brain?

At clinically relevant doses, modafinil significantly increases dopamine in the human brain by blocking dopamine transporters. Modafinil’s binding to the dopamine transporter overlaps with the binding site of cocaine because [11C]cocaine binding in striatum was inhibited by modafinil.

Does modafinil damage the brain?

Modafinil’s exact mechanism is unclear, though it affects many neurotransmitter systems in the brain. Some studies suggest it may enhance performance on complex tasks in healthy individuals; however, no long-term studies have tested whether modafinil prevents cognitive decline or dementia.

How long does 200mg of modafinil last?

Modafinil 200 mg adequately sustains performance at near baseline levels for up to 10 h. Despite early claims that modafinil does not interfere with sleep, results have shown that – similar to caffeine – modafinil impairs sleep if the sleep period is initiated within modafinil’s duration of action.

Can you drink alcohol on modafinil?

Do not drink alcohol while taking Modafinil as they can enhance each other’s side effects such as increased dehydration. Modafinil should be kept out of reach of children.

Can modafinil cause psychosis?

High dose of modafinil may induce positive psychotic symptoms similar with other stimulants such as amphetamine. The role of dopamine in positive psychotic symptoms is a well-known phenomenon.

How long can you stay up on modafinil?

In trials on healthy people, modafinil allowed users to stay up for almost two days while remaining nearly as focused, alert and capable of problem-solving as the well-rested. After eight hours of sleep, Garreau writes, users can rise and go another 40 hours.

Can you just stop taking modafinil?

If you suddenly stop using this medication, you may have withdrawal symptoms (such as shaking, sweating, chills, nausea, vomiting, confusion). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used modafinil for a long time or in high doses.

Is modafinil used for depression?

Abstract. Major depression is often refractory to antidepressants, and it is important to explore alternative medication treatments. Among the symptoms common with depression are energy loss/fatigue and anxiety. Modafinil has a novel mechanism of action and may have antidepressant properties.

Is modafinil bad for your liver?

Hepatotoxicity. In clinical trials, modafinil and armodafinil were associated with a low rate of serum aminotransferase and alkaline phosphatase elevations (<1%). Furthermore, despite widescale use, there have not been reports of clinically apparent liver injury due to modafinil or armodafinil.

Can you build up a tolerance to modafinil?

There is no evidence that tolerance develops to modafinil or that the drug impairs sleep quality (if taken in the morning). It has a number of advantages including once-daily dosing, low abuse potential, and the fact that it is not a schedule II medication.

Can I take modafinil on empty stomach?

It is usually taken once a day with or without food. If you are taking modafinil to treat narcolepsy or OSAHS, you will probably take it in the morning. If you are taking modafinil to treat shift work sleep disorder, you will probably take it 1 hour before the beginning of your work shift.